Supplements: What's Actually Worth Taking

Organised by strength of evidence, not by marketing spend

3 min read·Updated June 2026

The supplement industry is largely unregulated for efficacy claims, which means the evidence behind any given product varies enormously. This section stays focused on the training-specific angle — why lifters and athletes prioritise these particular options; see the Supplements guide for full dosing and evidence-strength detail on these and other options (vitamin D3/K2, magnesium, omega-3, creatine, and more).

Tier 1 — strong, consistent evidence

SupplementWhat it doesNotes
Creatine monohydrateWhy athletes care: tops up phosphocreatine (a molecule muscle uses to regenerate energy fastest, for short bursts of maximal effort), modestly improving high-intensity exercise capacity and supporting small additional gains in strength and muscle mass over time[58]3–5g/day; extensively studied, strong long-term safety record
CaffeineImproves alertness and measurably improves endurance and high-intensity performance at moderate doses[59]~3–6mg/kg bodyweight, roughly 45–60 minutes pre-exercise
Whey/casein proteinWhy athletes care: a convenient, complete protein source for hitting daily targets and post-workout intake without cooking or carrying foodNot superior to whole food protein gram-for-gram — purely a convenience tool
Vitamin DCorrects a genuinely common deficiency, particularly in winter or low sun-exposure contextsWorth testing blood levels rather than guessing dose

Tier 2 — reasonable evidence, smaller or context-dependent effect

SupplementWhat it doesNotes
Beta-alanineBuffers muscular acidity, may modestly help sustained high-intensity efforts (1–4 minutes)Typically 3.2–6.4g/day; causes harmless tingling (paraesthesia) at higher single doses[60]
Omega-3 (fish oil)Supports cardiovascular markers; relevant if oily fish intake is lowMost useful as a gap-filler, not a universal addition
Citrulline malateMay modestly improve training volume and reduce perceived fatigueEffects are smaller and less consistent than creatine
Magnesium (incl. glycinate)May improve sleep quality in people with poor sleep or low magnesium status200–400mg in the evening[61]
ZincModestly shortens the duration of common cold symptoms when started within 24 hours of onsetLozenges, ~75mg/day during a cold; chronic high-dose use can impair copper absorption[62]
L-theanine (with caffeine)Combined with caffeine, may improve sustained attention and reduce caffeine-related jitteriness versus caffeine alone~200mg with ~100mg caffeine[63]

Tier 3 — weak, inconsistent, or no credible evidence for the claims made

Fat burners / thermogenics — the only active ingredient that does anything is usually caffeine; the herbal blends around it rarely show independent benefit.

BCAAs (in isolation) — add nothing beyond what adequate total protein already supplies; skip if you're hitting your protein target.

Detox teas / cleanses — no real mechanism beyond a laxative or diuretic effect; any "weight loss" is water and gut content, not fat.

Testosterone boosters (over-the-counter) — almost none raise testosterone in men with normal baseline levels.

Alpha-GPC — marketed for strength and growth hormone output, but the supporting evidence is a single unpublished, unreplicated seven-person trial[64] — too thin to draw a conclusion either way.

Supplements supplement — they do not substitute

Every product in Tier 1 produces a measurable but modest effect on top of an already sound diet and training programme. None of them compensate for inadequate sleep, inconsistent training, or a calorie intake that does not match the goal. Spend the budget on food quality and consistency first.